Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer | Clinical Research Trial Listing (2025)

Table of Contents
Study Summary Eligibility Criteria Study Design Study Description Connect with a study center Cancer Center-Metro Medical Center Bayamon Doctors Cancer Center Centro Comprensivo de Cancer de UPR PROncology San Juan City Hospital San Juan Community Oncology Group Alaska Breast Care and Surgery LLC Alaska Oncology and Hematology LLC Alaska Women's Cancer Care Anchorage Associates in Radiation Medicine Anchorage Oncology Centre Anchorage Radiation Therapy Center Katmai Oncology Group Providence Alaska Medical Center Cancer Center at Saint Joseph's Mercy Hospital Fort Smith NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro CARTI Cancer Center Mission Hope Medical Oncology - Arroyo Grande Sutter Auburn Faith Hospital Sutter Cancer Centers Radiation Oncology Services-Auburn Alta Bates Summit Medical Center-Herrick Campus Tower Cancer Research Foundation Providence Saint Joseph Medical Center/Disney Family Cancer Center Sutter Cancer Centers Radiation Oncology Services-Cameron Park Mercy Cancer Center �� Carmichael Mercy San Juan Medical Center Eden Hospital Medical Center Sutter Davis Hospital Mercy Cancer Center - Elk Grove Palo Alto Medical Foundation-Fremont Cedars Sinai Medical Center Memorial Medical Center Palo Alto Medical Foundation-Camino Division Palo Alto Medical Foundation-Gynecologic Oncology Providence Queen of The Valley Sutter Cancer Research Consortium Desert Regional Medical Center Palo Alto Medical Foundation Health Care Mercy Cancer Center - Rocklin Sutter Cancer Centers Radiation Oncology Services-Roseville Sutter Roseville Medical Center Mercy Cancer Center - Sacramento Sutter Medical Center Sacramento California Pacific Medical Center-Pacific Campus Pacific Central Coast Health Center-San Luis Obispo Mills Health Center Palo Alto Medical Foundation-Santa Cruz Mission Hope Medical Oncology - Santa Maria Providence Medical Foundation - Santa Rosa Providence Santa Rosa Memorial Hospital Sutter Pacific Medical Foundation Palo Alto Medical Foundation-Sunnyvale Cedars-Sinai Cancer - Tarzana Torrance Memorial Physician Network - Cancer Care Sutter Solano Medical Center/Cancer Center Woodland Memorial Hospital Penrose-Saint Francis Healthcare Rocky Mountain Cancer Centers-Penrose Saint Francis Cancer Center National Jewish Health-Main Campus Porter Adventist Hospital SCL Health Saint Joseph Hospital Mercy Medical Center Southwest Oncology PC National Jewish Health-Western Hematology Oncology SCL Health Cancer Centers of Colorado - Lutheran Medical Center Saint Anthony Hospital Littleton Adventist Hospital Longmont United Hospital Parker Adventist Hospital Saint Mary Corwin Medical Center National Jewish Health-Northern Hematology Oncology SCL Health Lutheran Medical Center Beebe South Coastal Health Campus Beebe Medical Center Christiana Care Health System-Christiana Hospital Delaware Clinical and Laboratory Physicians PA Helen F Graham Cancer Center Medical Oncology Hematology Consultants PA Beebe Health Campus Christiana Care Health System-Wilmington Hospital The Watson Clinic Lewis Hall Singletary Oncology Center Saint Alphonsus Cancer Care Center-Boise Saint Luke's Cancer Institute - Boise Saint Alphonsus Cancer Care Center-Caldwell Kootenai Health - Coeur d'Alene Walter Knox Memorial Hospital Saint Luke's Cancer Institute - Fruitland Idaho Urologic Institute-Meridian Saint Luke's Cancer Institute - Meridian Saint Alphonsus Cancer Care Center-Nampa Saint Luke's Cancer Institute - Nampa Kootenai Clinic Cancer Services - Post Falls Kootenai Cancer Clinic Saint Luke's Cancer Institute - Twin Falls Saint Anthony's Health Rush - Copley Medical Center Illinois CancerCare-Bloomington Illinois CancerCare-Canton Memorial Hospital of Carbondale SIH Cancer Institute Illinois CancerCare-Carthage Centralia Oncology Clinic Saint Mary's Hospital Northwestern University Carle at The Riverfront Northwestern Medicine Cancer Center Kishwaukee Cancer Care Specialists of Illinois - Decatur Decatur Memorial Hospital Illinois CancerCare-Dixon Carle Physician Group-Effingham Crossroads Cancer Center Illinois CancerCare-Eureka Illinois CancerCare-Galesburg Western Illinois Cancer Treatment Center Northwestern Medicine Cancer Center Delnor Illinois CancerCare-Kewanee Clinic Northwestern Medicine Lake Forest Hospital Illinois CancerCare-Macomb Carle Physician Group-Mattoon/Charleston Good Samaritan Regional Health Center Cancer Care Center of O'Fallon Northwestern Medicine Orland Park Illinois CancerCare-Ottawa Clinic Illinois CancerCare-Pekin Illinois CancerCare-Peoria Methodist Medical Center of Illinois Illinois CancerCare-Peru Valley Radiation Oncology Illinois CancerCare-Princeton SwedishAmerican Regional Cancer Center/ACT Memorial Medical Center Southern Illinois University School of Medicine Springfield Clinic Carle Cancer Center Northwestern Medicine Cancer Center Warrenville Illinois CancerCare - Washington Rush-Copley Healthcare Center Reid Health Mercy Hospital Oncology Associates at Mercy Medical Center Medical Oncology and Hematology Associates-West Des Moines Mercy Cancer Center-West Lakes Alegent Health Mercy Hospital Greater Regional Medical Center Mercy Medical Center - Des Moines Mission Cancer and Blood - Laurel Mercy Medical Center-West Lakes Cancer Center of Kansas - Chanute Cancer Center of Kansas - Dodge City Cancer Center of Kansas - El Dorado Central Care Cancer Center - Garden City Central Care Cancer Center - Great Bend HaysMed University of Kansas Health System Cancer Center of Kansas-Independence University of Kansas Cancer Center Cancer Center of Kansas-Kingman Lawrence Memorial Hospital Cancer Center of Kansas-Liberal Cancer Center of Kansas-Manhattan Cancer Center of Kansas - McPherson Cancer Center of Kansas - Newton Olathe Health Cancer Center Cancer Center of Kansas - Parsons Cancer Center of Kansas - Pratt Cancer Center of Kansas - Salina Salina Regional Health Center University of Kansas Health System Saint Francis Campus Cancer Center of Kansas - Wellington Ascension Via Christi Hospitals Wichita Cancer Center of Kansas - Wichita Cancer Center of Kansas-Wichita Medical Arts Tower Cancer Center of Kansas - Winfield Flaget Memorial Hospital Commonwealth Cancer Center-Corbin Saint Joseph Hospital Saint Joseph Hospital East Saint Joseph Radiation Oncology Resource Center Saint Joseph London Saint Joseph Mount Sterling Louisiana State University Health Science Center University Medical Center New Orleans Christiana Care - Union Hospital Beverly Hospital Lahey Hospital and Medical Center Addison Gilbert Hospital Lahey Medical Center-Peabody Winchester Hospital Hickman Cancer Center Saint Joseph Mercy Hospital Saint Joseph Mercy Brighton Trinity Health IHA Medical Group Hematology Oncology - Brighton Saint Joseph Mercy Canton Trinity Health IHA Medical Group Hematology Oncology - Canton Caro Cancer Center Saint Joseph Mercy Chelsea Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Hematology Oncology Consultants-Clarkston Newland Medical Associates-Clarkston Beaumont Hospital - Dearborn Ascension Saint John Hospital Great Lakes Cancer Management Specialists-Doctors Park Beaumont Hospital - Farmington Hills Genesee Cancer and Blood Disease Treatment Center Genesee Hematology Oncology PC Genesys Hurley Cancer Institute Hurley Medical Center Academic Hematology Oncology Specialists Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Sparrow Hospital Trinity Health Saint Mary Mercy Livonia Hospital Great Lakes Cancer Management Specialists-Macomb Medical Campus Saint Mary's Oncology/Hematology Associates of Marlette Toledo Clinic Cancer Centers-Monroe 21st Century Oncology-Pontiac Hope Cancer Center Newland Medical Associates-Pontiac Saint Joseph Mercy Oakland Cancer Care Associates PC Comprehensive Medical Center PLLC Hematology Oncology Consultants PC Oakland Colon Rectal Associates Oakland Medical Group William Beaumont Hospital-Royal Oak Ascension Saint Mary's Hospital Oncology Hematology Associates of Saginaw Valley PC Bhadresh Nayak MD PC-Sterling Heights Premier Hematology Oncology Care Ascension Saint Joseph Hospital Hematology Oncology Consultants PC-Troy Michigan Institute of Urology-Town Center William Beaumont Hospital - Troy Advanced Breast Care Center PLLC Great Lakes Cancer Management Specialists-Macomb Professional Building Macomb Hematology Oncology PC Michigan Breast Specialists-Warren Saint John Macomb-Oakland Hospital Saint Mary's Oncology/Hematology Associates of West Branch Huron Gastroenterology PC Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Sanford Joe Lueken Cancer Center Minnesota Oncology - Burnsville Cambridge Medical Center Mercy Hospital Fairview Southdale Hospital Unity Hospital Fairview Clinics and Surgery Center Maple Grove Minnesota Oncology Hematology PA-Maplewood Saint John's Hospital - Healtheast Abbott-Northwestern Hospital Health Partners Inc Hennepin County Medical Center Monticello Cancer Center New Ulm Medical Center Fairview Northland Medical Center North Memorial Medical Health Center Park Nicollet Clinic - Saint Louis Park Regions Hospital United Hospital Saint Francis Regional Medical Center Lakeview Hospital Sanford Thief River Falls Medical Center Ridgeview Medical Center Rice Memorial Hospital Minnesota Oncology Hematology PA-Woodbury Sanford Cancer Center Worthington Fairview Lakes Medical Center Baptist Memorial Hospital and Cancer Center-Golden Triangle Baptist Cancer Center-Grenada University of Mississippi Medical Center Baptist Memorial Hospital and Cancer Center-Union County Baptist Memorial Hospital and Cancer Center-Oxford Baptist Memorial Hospital and Cancer Center-Desoto Saint Louis Cancer and Breast Institute-Ballwin Central Care Cancer Center - Bolivar Cox Cancer Center Branson Saint Francis Medical Center Southeast Cancer Center Parkland Health Center - Farmington Capital Region Southwest Campus Freeman Health System Mercy Hospital Joplin Truman Medical Centers Lake Regional Hospital Delbert Day Cancer Institute at PCRMC Mercy Clinic-Rolla-Cancer and Hematology Heartland Regional Medical Center Mercy Hospital Saint Louis Mercy Hospital South Missouri Baptist Medical Center Saint Louis Cancer and Breast Institute-South City Sainte Genevieve County Memorial Hospital CoxHealth South Hospital Mercy Hospital Springfield Missouri Baptist Sullivan Hospital Missouri Baptist Outpatient Center-Sunset Hills Mercy Hospital Washington Community Hospital of Anaconda Billings Clinic Cancer Center Bozeman Deaconess Hospital Benefis Healthcare- Sletten Cancer Institute Great Falls Clinic Kalispell Regional Medical Center Community Medical Hospital Saint Patrick Hospital - Community Hospital CHI Health Good Samaritan Saint Elizabeth Regional Medical Center Alegent Health Bergan Mercy Medical Center Alegent Health Immanuel Medical Center Alegent Health Lakeside Hospital Creighton University Medical Center Midlands Community Hospital Glens Falls Hospital Stony Brook University Medical Center South Nassau Cancer Center AdventHealth Infusion Center Asheville AdventHealth Infusion Center Haywood AdventHealth Hendersonville Margaret R Pardee Memorial Hospital FirstHealth of the Carolinas-Moore Regional Hospital AdventHealth Infusion Center Weaverville Sanford Bismarck Medical Center Sanford Broadway Medical Center Sanford Medical Center Fargo Sanford Roger Maris Cancer Center Sanford South University Medical Center Southpointe-Sanford Medical Center Fargo Indu and Raj Soin Medical Center Saint Elizabeth Boardman Hospital Dayton Physicians LLC-Miami Valley South Miami Valley Hospital South Bethesda North Hospital Good Samaritan Hospital - Cincinnati Oncology Hematology Care Inc-Kenwood TriHealth Cancer Institute-Anderson TriHealth Cancer Institute-Westside Dayton Blood and Cancer Center Dayton Physician LLC-Miami Valley Hospital North Miami Valley Hospital Miami Valley Hospital North Armes Family Cancer Center Blanchard Valley Hospital Orion Cancer Care Atrium Medical Center-Middletown Regional Hospital Dayton Physicians LLC-Atrium Dayton Physicians LLC-Wayne Wayne Hospital Greater Dayton Cancer Center Kettering Medical Center Toledo Clinic Cancer Centers-Maumee Toledo Clinic Cancer Centers-Toledo Dayton Physicians LLC - Troy Upper Valley Medical Center Saint Joseph Warren Hospital Saint Elizabeth Youngstown Hospital Mercy Hospital Oklahoma City University of Oklahoma Health Sciences Center Saint Alphonsus Medical Center-Baker City Saint Charles Health System Clackamas Radiation Oncology Center Providence Cancer Institute Clackamas Clinic Bay Area Hospital Legacy Mount Hood Medical Center Providence Newberg Medical Center Saint Alphonsus Medical Center-Ontario Providence Willamette Falls Medical Center Legacy Good Samaritan Hospital and Medical Center Providence Portland Medical Center Providence Saint Vincent Medical Center Saint Charles Health System-Redmond Legacy Meridian Park Hospital Lehigh Valley Hospital-Cedar Crest Lehigh Valley Hospital - Muhlenberg Bryn Mawr Hospital Christiana Care Health System-Concord Health Center Main Line Health Center-Collegeville Pocono Medical Center Main Line Health Center-Exton Lehigh Valley Hospital-Hazleton Riddle Memorial Hospital Bryn Mawr Health Center Paoli Memorial Hospital Lankenau Medical Center Women and Infants Hospital Prisma Health Cancer Institute - Spartanburg Prisma Health Cancer Institute - Easley Prisma Health Cancer Institute - Butternut Prisma Health Cancer Institute - Eastside Prisma Health Cancer Institute - Faris Prisma Health Cancer Institute - Greer Prisma Health Cancer Institute - Seneca Lexington Medical Center Sanford Cancer Center Oncology Clinic Sanford USD Medical Center - Sioux Falls Baptist Memorial Hospital and Cancer Center-Collierville Baptist Memorial Hospital and Cancer Center-Memphis Bon Secours Memorial Regional Medical Center Bon Secours Saint Francis Medical Center Bon Secours Westchester Emergency Center Bon Secours Cancer Institute at Reynolds Crossing Bon Secours Richmond Community Hospital Bon Secours Saint Mary's Hospital Providence Regional Cancer System-Aberdeen PeaceHealth Saint Joseph Medical Center Harrison Medical Center Providence Regional Cancer System-Centralia Swedish Cancer Institute-Edmonds Providence Regional Cancer Partnership Swedish Cancer Institute-Issaquah Kadlec Clinic Hematology and Oncology Providence Regional Cancer System-Lacey PeaceHealth Saint John Medical Center Swedish Medical Center-Ballard Campus Swedish Medical Center-Cherry Hill Swedish Medical Center-First Hill PeaceHealth United General Medical Center Providence Regional Cancer System-Shelton Legacy Cancer Institute Medical Oncology and Day Treatment Legacy Salmon Creek Hospital PeaceHealth Southwest Medical Center Providence Saint Mary Regional Cancer Center Providence Regional Cancer System-Yelm Marshfield Medical Center-EC Cancer Center Marshfield Medical Center-Marshfield Marshfield Clinic-Minocqua Center Cancer Center of Western Wisconsin Marshfield Medical Center-Rice Lake Marshfield Medical Center-River Region at Stevens Point Marshfield Medical Center - Weston Billings Clinic-Cody Welch Cancer Center Not the study for you? FAQs References

Last updated: October 24, 2023

Sponsor: SWOG Cancer Research Network

Overall Status: Active - Recruiting

Phase

3

Condition

N/A

Treatment

Quality-of-Life Assessment

Paclitaxel

Pembrolizumab

Clinical Study ID

NCT05929768

S2212

NCI-2023-02688

S2212

U10CA180888

  • Ages > 18
  • All Genders

Study Summary

This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapywithout anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triplenegative breast cancer. Paclitaxel is in a class of medications called anti-microtubuleagents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is ina class of medications known as platinum-containing compounds. It works in a way similar tothe anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin worksby killing, stopping or slowing the growth of cancer cells. Cyclophosphamide is in a class ofmedications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid(DNA) and may kill cancer cells. It may also lower the body's immune response. Docetaxel isin a class of medications called taxanes. It stops cancer cells from growing and dividing andmay kill them. Doxorubicin is an anthracycline chemotherapy drug that damages DNA and maykill cancer cells. Pembrolizumab may stop the growth of tumor cells by blocking some of theenzymes needed for cell growth. Shorter treatment without anthracycline chemotherapy may workthe same as the usual anthracycline chemotherapy treatment for early-stage triple negativebreast cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants must have histologically confirmed estrogen receptor (ER)-negative,progesterone receptor (PR)-negative, and HER2-negative breast cancer (TNBC) defined asER < 5%, PR < 5%, and HER2 negative (per 2020 American Society of Clinical Oncology[ASCO] College of American Pathologists [CAP] guidelines)

  • NOTE: Participants with weakly ER or PR positive disease, defined as ER and/or PRbetween 1-4% by immunohistochemistry, are eligible if adjuvant endocrine therapyis not recommended/planned by the treating physician

  • Participants must have American Joint Committee on Cancer (AJCC) 8 anatomic tumorclinical stage either

  • T2-T4, N0, M0 or

  • T1-T3, N1-2, M0

  • Note: All participants with clinically suspicious nodes must undergo core needlebiopsy or fine needle biopsy per standard clinical practice to pathologicallyconfirm nodal status

  • Participants must have breast and axillary imaging with mammogram and/or ultrasoundand/or magnetic resonance imaging (MRI) within 49 days prior to randomization

  • Note: Participants with bilateral invasive breast cancer are eligible if bothbreast cancers are ER-negative, PR-negative, and HER2-negative provided they meetthe other eligibility criteria

  • Participants must not have T4/N+, any N3, or inflammatory breast cancer

  • Participants must not have metastatic disease (M1)

  • Participants must not have received prior systemic therapy or radiation therapy withcurative intent for the current breast cancer

  • Participants must not have had previous definitive ipsilateral breast surgery for thecurrent breast cancer

  • Participants must not have current or anticipated use of other investigational agentswhile participating in this study

  • Participants must not have history of allergic reactions attributed to compounds ofsimilar chemical or biologic composition as study agents

  • Participants must not have severe hypersensitivity (>= grade 3) to pembrolizumab orany of its excipients

  • Participants must not have received prior therapy with an anti-PD-1, anti-PD-L1, oranti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitoryT-cell receptor (e.g. CTLA-4, OX-40, CD137)

  • Participants must not be currently participating in or have participated in a study ofan investigational agent or used an investigational device within 28 days prior torandomization

  • Participants must be >= 18 years old

  • Participants must have Zubrod performance status of 0-2

  • Participants with evidence of peripheral neuropathy must have it at =< grade 1, byCommon Terminology Criteria for Adverse Events (CTCAE) version (v.) 5.0, within 28days prior to randomization

  • Participants must have a complete medical history and physical exam within 28 daysprior to randomization

  • Hemoglobin >= 9.0 g/dL or >= 5.6 mol/L (within 28 days prior to randomization)

  • (Criteria must be met without erythropoietin dependency and without packed redblood cell transfusion within last 2 weeks)

  • Leukocytes >= 3 x 10^3/uL (within 28 days prior to randomization)

  • Absolute neutrophil count >= 1.5 x 10^3/uL (within 28 days prior to randomization)

  • Platelets >= 100 x 10^3/uL (within 28 days prior to randomization)

  • Total bilirubin =< 1.5 x institutional upper limit of normal (IULN), OR directbilirubin =< IULN for participants with total bilirubin > 1.5 x IULN (unless historyof Gilbert's disease. Participants with history of Gilbert's disease must have totalbilirubin =< 5 x institutional IULN) (within 28 days prior to randomization)

  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 xinstitutional upper limit of normal (ULN) (within 28 days prior to randomization)

  • Participants must have a serum creatinine =< the IULN OR calculated creatinineclearance >= 50 mL/min/1.73m^2 using the following Cockcroft-Gault Formula. Thisspecimen must have been drawn and processed within 28 days prior to registration

  • Participants must have adequate cardiac function. Participants must have leftventricular ejection fraction >= 50% as assessed by either echocardiography (ECHO) ormultigated acquisition scan (MUGA) assessed within 28 days prior to registration.Participants with known history or current symptoms of cardiac disease, or history oftreatment with cardiotoxic agents, must have a clinical risk assessment of cardiacfunction using the New York Heart Association Functional Classification and must beclass 2B or better

  • Participants with known human immunodeficiency virus (HIV)-infection must be oneffective anti-retroviral therapy at randomization and have undetectable viral loadtest on the most recent test results obtained within 6 months prior to randomization

  • Participants with evidence of chronic hepatitis B virus (HBV) infection must haveundetectable HBV viral load while on suppressive therapy on the most recent testresults obtained within 6 months prior to randomization, if indicated

  • Note: No testing for Hepatitis B is required unless mandated by local healthauthority

  • Participants with a history of hepatitis C virus (HCV) infection must have beentreated and cured. Participants currently being treated for HCV infection must haveundetectable HCV viral load test on the most recent test results obtained within 6months prior to randomization, if indicated

  • Note: No testing for hepatitis C is required unless mandated by local healthauthority

  • Participants with history of diabetes must not have uncontrolled diabetes in theopinion of the treating investigator

  • Participants must not have uncontrolled hypertension in the opinion of the treatinginvestigator

  • Participants must not have had a major surgery within 14 days prior to randomization.Participants must have fully recovered from the effects of prior major surgery in theopinion of the treating investigator

  • Participants must not have severe or active infections within 14 days prior toRandomization, including but not limited to hospitalization for infection, bacteremia,or severe pneumonia

  • Participants must not have a diagnosis of immunodeficiency and be receiving chronicsystemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) orany other form of immunosuppressive therapy within 7 days prior to randomization

  • Participants must not have active autoimmune disease that has required systemictreatment in 2 years prior to randomization (i.e., with use of disease modifyingagents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g.,thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal orpituitary insufficiency) is not considered a form of systemic treatment

  • Participants must not have a history of (non-infectious) pneumonitis that requiredsteroids, or has current (non-infectious) pneumonitis

  • Participants must not have received a live vaccine within 30 days prior torandomization. Examples of live vaccines include, but are not limited to, thefollowing: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever,rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenzavaccines for injection are generally killed virus vaccines and are allowed; however,intranasal influenza vaccines (e.g., FluMist [registered trademark]) are liveattenuated vaccines and are not allowed

  • Participants must not have a prior or concurrent malignancy whose natural history ortreatment (in the opinion of the treating physician) has the potential to interferewith the safety or efficacy assessment of the treatment regimen

  • Participants must not be pregnant or nursing. Individuals who are of reproductivepotential must have agreed to use an effective contraceptive method with detailsprovided as a part of the consent process. A person who has had menses at any time inthe preceding 12 consecutive months or who has semen likely to contain sperm isconsidered to be of "reproductive potential." In addition to routine contraceptivemethods, "effective contraception" also includes refraining from sexual activity thatmight result in pregnancy and surgery intended to prevent pregnancy (or with aside-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy,bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in thesemen

  • Participants must have one (1) physical 4-5-micron single hematoxylin and eosin (H&E)slide from the archival pretreatment diagnostic biopsy available for submission

  • Participants must be offered the opportunity to participate in specimen banking. Withparticipant consent, specimens must be collected and submitted via the SouthwestOncology Group (SWOG) Specimen Tracking System

  • Participants who can complete questionnaires in English, Spanish, or French must beoffered the opportunity to participate in the Patient-Reported Outcome study

  • NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration processthe treating institution's identity is provided in order to ensure that the current(within 365 days) date of institutional review board approval for this study has beenentered in the system

  • Participants must be informed of the investigational nature of this study andmust sign and give informed consent in accordance with institutional and federalguidelines

  • For participants with impaired decision-making capabilities, legally authorizedrepresentatives may sign and give informed consent on behalf of studyparticipants in accordance with applicable federal, local, and CentralInstitutional Review Board (CIRB) regulations

  • As part of the registration process the treating institution's identity is provided inorder to ensure that the current (within 365 days) date of institutional review boardapproval for this study has been entered in the system

Study Design

Total Participants: 2400

Treatment Group(s): 10

Primary Treatment: Quality-of-Life Assessment

Phase: 3

Study Start date:

September 15, 2023

Estimated Completion Date:

April 30, 2033

Study Description

PRIMARY OBJECTIVE:

I. To assess whether participants with early stage triple negative breast cancer (TNBC)randomized to receive anthracycline-free, taxane-platinum neoadjuvant chemotherapy withpembrolizumab have non-inferior breast cancer event-free survival (BC-EFS) compared toparticipants randomized to taxane-platinum-anthracycline neoadjuvant chemotherapy withpembrolizumab.

SECONDARY OBJECTIVES:

I. To compare pathological complete response (pCR) and residual cancer burden (RCB) rates byrandomized arm.

II. To compare pCR and RCB rates between randomized arms by tumor infiltrating lymphocytes(TIL) status.

III. To compare BC-EFS between randomized arms in the TIL-enriched and non-TIL enrichedsubgroups.

IV. To compare distant relapse-free survival and overall survival by randomized arm.

V. To compare invasive breast cancer-free survival after surgery between randomized arms inpCR and residual disease groups.

VI. To compare the safety and tolerability by randomized arm among those that initiatetherapy.

TRANSLATIONAL MEDICINE OBJECTIVE:

I. To evaluate concordance and accuracy of an automated stromal TIL (sTIL) algorithm versus(vs.) central pathologist assessed sTILs quantification.

PATIENT REPORTED OUTCOME (PRO) OBJECTIVES:

I. To compare patient-reported fatigue at 3 weeks after the last neoadjuvant systemic therapy(NAST) dose and, separately, at 18 months after randomization, using the Patient ReportedOutcomes Measurement Information System (PROMIS) Fatigue-7a in participants undergoing NASTwith taxane-platinum-anthracycline chemo-immunotherapy vs taxane-platinumchemo-immunotherapy. (Quality of Life, Primary) II. To compare physical function experiencedby participants undergoing neoadjuvant systemic chemotherapy (NAST) withtaxane-platinum-anthracycline chemo-immunotherapy vs taxane-platinum chemo-immunotherapy,within 3-5 weeks post last neoadjuvant systemic therapy dose using the PROMIS-29 Profilephysical function subscale score. (Quality of Life, Secondary) III. To compare physicalfunction experienced by participants undergoing NAST taxane-platinum-anthracyclinechemo-immunotherapy vs taxane-platinum chemo-immunotherapy at 18 months post registrationusing the PROMIS-29 Profile physical function subscale score. (Quality of Life, Secondary)IV. To compare other PROMIS-29 Profile subscale scores (sleep disturbance, depression,anxiety, social, pain interference, and pain sensitivity) and GP5 question response by armwithin 3-5 weeks post last neoadjuvant systemic therapy dose and at 18 months postregistration. (Quality of Life, Exploratory) V. To compare the GP-5 item scores by arm within3-5 weeks post last neoadjuvant systemic therapy dose and at 18 months post registration.(Quality of Life, Exploratory) VI. To compare select patient-reported outcomes using theCommon Terminology Criteria for Adverse Events (PRO-CTCAE) by arm. (Patient-Reported Symptomsof Treatment)

BANKING OBJECTIVE:

I. To bank physical specimens and digital slides for future correlative studies.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive paclitaxel intravenously (IV), carboplatin IV, and pembrolizumab IVon study. Patients then receive doxorubicin IV, cyclophosphamide IV, and pembrolizumab IV onstudy. Patients then undergo surgery. Patients may receive pembrolizumab after surgery.Patients may optionally undergo collection of blood samples throughout the trial.

ARM II: Patients receive docetaxel IV, carboplatin IV, and pembrolizumab IV on study.Patients then undergo surgery. Patients may receive pembrolizumab after surgery. Patients mayoptionally undergo collection of blood samples throughout the trial.

Patients are followed up every 6 months for the first 2 years and then annually until 5 yearsfrom registration.

Connect with a study center

  • Cancer Center-Metro Medical Center Bayamon

    Bayamon, 00959-5060
    Puerto Rico

    Active - Recruiting

  • Doctors Cancer Center

    Manati, 00674
    Puerto Rico

    Active - Recruiting

  • Centro Comprensivo de Cancer de UPR

    San Juan, 00927
    Puerto Rico

    Active - Recruiting

  • PROncology

    San Juan, 00927
    Puerto Rico

    Active - Recruiting

  • San Juan City Hospital

    San Juan, 00936
    Puerto Rico

    Active - Recruiting

  • San Juan Community Oncology Group

    San Juan, 00917
    Puerto Rico

    Active - Recruiting

  • Alaska Breast Care and Surgery LLC

    Anchorage, Alaska 99508
    United States

    Active - Recruiting

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska 99508
    United States

    Active - Recruiting

  • Alaska Women's Cancer Care

    Anchorage, Alaska 99508
    United States

    Active - Recruiting

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska 98508
    United States

    Active - Recruiting

  • Anchorage Oncology Centre

    Anchorage, Alaska 99508
    United States

    Active - Recruiting

  • Anchorage Radiation Therapy Center

    Anchorage, Alaska 99504
    United States

    Active - Recruiting

  • Katmai Oncology Group

    Anchorage, Alaska 99508
    United States

    Active - Recruiting

  • Providence Alaska Medical Center

    Anchorage, Alaska 99508
    United States

    Active - Recruiting

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona 85004
    United States

    Active - Recruiting

  • Mercy Hospital Fort Smith

    Fort Smith, Arkansas 72903
    United States

    Active - Recruiting

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas 72401
    United States

    Active - Recruiting

  • CARTI Cancer Center

    Little Rock, Arkansas 72205
    United States

    Active - Recruiting

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California 93420
    United States

    Active - Recruiting

  • Sutter Auburn Faith Hospital

    Auburn, California 95602
    United States

    Active - Recruiting

  • Sutter Cancer Centers Radiation Oncology Services-Auburn

    Auburn, California 95603
    United States

    Active - Recruiting

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California 94704
    United States

    Active - Recruiting

  • Tower Cancer Research Foundation

    Beverly Hills, California 90211
    United States

    Active - Recruiting

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California 91505
    United States

    Active - Recruiting

  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park

    Cameron Park, California 95682
    United States

    Active - Recruiting

  • Mercy Cancer Center �� Carmichael

    Carmichael, California 95608
    United States

    Active - Recruiting

  • Mercy San Juan Medical Center

    Carmichael, California 95608
    United States

    Active - Recruiting

  • Eden Hospital Medical Center

    Castro Valley, California 94546
    United States

    Active - Recruiting

  • Sutter Davis Hospital

    Davis, California 95616
    United States

    Active - Recruiting

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California 95758
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Fremont

    Fremont, California 94538
    United States

    Active - Recruiting

  • Cedars Sinai Medical Center

    Los Angeles, California 90048
    United States

    Active - Recruiting

  • Memorial Medical Center

    Modesto, California 95355
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California 94040
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Gynecologic Oncology

    Mountain View, California 94040
    United States

    Active - Recruiting

  • Providence Queen of The Valley

    Napa, California 94558
    United States

    Active - Recruiting

  • Sutter Cancer Research Consortium

    Novato, California 94945
    United States

    Active - Recruiting

  • Desert Regional Medical Center

    Palm Springs, California 92262
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California 94301
    United States

    Active - Recruiting

  • Mercy Cancer Center - Rocklin

    Rocklin, California 95765
    United States

    Active - Recruiting

  • Sutter Cancer Centers Radiation Oncology Services-Roseville

    Roseville, California 95661
    United States

    Active - Recruiting

  • Sutter Roseville Medical Center

    Roseville, California 95661
    United States

    Active - Recruiting

  • Mercy Cancer Center - Sacramento

    Sacramento, California 95816
    United States

    Active - Recruiting

  • Sutter Medical Center Sacramento

    Sacramento, California 95816
    United States

    Active - Recruiting

  • California Pacific Medical Center-Pacific Campus

    San Francisco, California 94115
    United States

    Active - Recruiting

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California 93401
    United States

    Active - Recruiting

  • Mills Health Center

    San Mateo, California 94401
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Santa Cruz

    Santa Cruz, California 95065
    United States

    Active - Recruiting

  • Mission Hope Medical Oncology - Santa Maria

    Santa Maria, California 93444
    United States

    Active - Recruiting

  • Providence Medical Foundation - Santa Rosa

    Santa Rosa, California 95403
    United States

    Active - Recruiting

  • Providence Santa Rosa Memorial Hospital

    Santa Rosa, California 95405
    United States

    Active - Recruiting

  • Sutter Pacific Medical Foundation

    Santa Rosa, California 95403
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California 94086
    United States

    Active - Recruiting

  • Cedars-Sinai Cancer - Tarzana

    Tarzana, California 91356
    United States

    Active - Recruiting

  • Torrance Memorial Physician Network - Cancer Care

    Torrance, California 90505
    United States

    Active - Recruiting

  • Sutter Solano Medical Center/Cancer Center

    Vallejo, California 94589
    United States

    Active - Recruiting

  • Woodland Memorial Hospital

    Woodland, California 95695
    United States

    Active - Recruiting

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado 80907
    United States

    Active - Recruiting

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado 80907
    United States

    Active - Recruiting

  • Saint Francis Cancer Center

    Colorado Springs, Colorado 80923
    United States

    Active - Recruiting

  • National Jewish Health-Main Campus

    Denver, Colorado 80206
    United States

    Active - Recruiting

  • Porter Adventist Hospital

    Denver, Colorado 80210
    United States

    Active - Recruiting

  • SCL Health Saint Joseph Hospital

    Denver, Colorado 80218
    United States

    Active - Recruiting

  • Mercy Medical Center

    Durango, Colorado 81301
    United States

    Active - Recruiting

  • Southwest Oncology PC

    Durango, Colorado 81301
    United States

    Active - Recruiting

  • National Jewish Health-Western Hematology Oncology

    Golden, Colorado 80401
    United States

    Active - Recruiting

  • SCL Health Cancer Centers of Colorado - Lutheran Medical Center

    Golden, Colorado 80401
    United States

    Active - Recruiting

  • Saint Anthony Hospital

    Lakewood, Colorado 80228
    United States

    Active - Recruiting

  • Littleton Adventist Hospital

    Littleton, Colorado 80122
    United States

    Active - Recruiting

  • Longmont United Hospital

    Longmont, Colorado 80501
    United States

    Active - Recruiting

  • Parker Adventist Hospital

    Parker, Colorado 80138
    United States

    Active - Recruiting

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado 81004
    United States

    Active - Recruiting

  • National Jewish Health-Northern Hematology Oncology

    Thornton, Colorado 80260
    United States

    Active - Recruiting

  • SCL Health Lutheran Medical Center

    Wheat Ridge, Colorado 80033
    United States

    Active - Recruiting

  • Beebe South Coastal Health Campus

    Frankford, Delaware 19945
    United States

    Active - Recruiting

  • Beebe Medical Center

    Lewes, Delaware 19958
    United States

    Active - Recruiting

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware 19718
    United States

    Active - Recruiting

  • Helen F Graham Cancer Center

    Newark, Delaware 19713
    United States

    Active - Recruiting

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware 19713
    United States

    Active - Recruiting

  • Beebe Health Campus

    Rehoboth Beach, Delaware 19971
    United States

    Active - Recruiting

  • Christiana Care Health System-Wilmington Hospital

    Wilmington, Delaware 19801
    United States

    Active - Recruiting

  • The Watson Clinic

    Lakeland, Florida 33805
    United States

    Active - Recruiting

  • Lewis Hall Singletary Oncology Center

    Thomasville, Georgia 31792
    United States

    Active - Recruiting

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho 83706
    United States

    Active - Recruiting

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho 83712
    United States

    Active - Recruiting

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho 83605
    United States

    Active - Recruiting

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho 83814
    United States

    Active - Recruiting

  • Walter Knox Memorial Hospital

    Emmett, Idaho 83617
    United States

    Active - Recruiting

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho 83619
    United States

    Active - Recruiting

  • Idaho Urologic Institute-Meridian

    Meridian, Idaho 83642
    United States

    Active - Recruiting

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho 83642
    United States

    Active - Recruiting

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho 83687
    United States

    Active - Recruiting

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho 83686
    United States

    Active - Recruiting

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho 83854
    United States

    Active - Recruiting

  • Kootenai Cancer Clinic

    Sandpoint, Idaho 83864
    United States

    Active - Recruiting

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho 83301
    United States

    Active - Recruiting

  • Saint Anthony's Health

    Alton, Illinois 62002
    United States

    Active - Recruiting

  • Rush - Copley Medical Center

    Aurora, Illinois 60504
    United States

    Active - Recruiting

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois 61704
    United States

    Active - Recruiting

  • Illinois CancerCare-Canton

    Canton, Illinois 61520
    United States

    Active - Recruiting

  • Memorial Hospital of Carbondale

    Carbondale, Illinois 62902
    United States

    Active - Recruiting

  • SIH Cancer Institute

    Carterville, Illinois 62918
    United States

    Active - Recruiting

  • Illinois CancerCare-Carthage

    Carthage, Illinois 62321
    United States

    Active - Recruiting

  • Centralia Oncology Clinic

    Centralia, Illinois 62801
    United States

    Active - Recruiting

  • Saint Mary's Hospital

    Centralia, Illinois 62801
    United States

    Active - Recruiting

  • Northwestern University

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • Carle at The Riverfront

    Danville, Illinois 61832
    United States

    Active - Recruiting

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois 60115
    United States

    Active - Recruiting

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois 62526
    United States

    Active - Recruiting

  • Decatur Memorial Hospital

    Decatur, Illinois 62526
    United States

    Active - Recruiting

  • Illinois CancerCare-Dixon

    Dixon, Illinois 61021
    United States

    Active - Recruiting

  • Carle Physician Group-Effingham

    Effingham, Illinois 62401
    United States

    Active - Recruiting

  • Crossroads Cancer Center

    Effingham, Illinois 62401
    United States

    Active - Recruiting

  • Illinois CancerCare-Eureka

    Eureka, Illinois 61530
    United States

    Active - Recruiting

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois 61401
    United States

    Active - Recruiting

  • Western Illinois Cancer Treatment Center

    Galesburg, Illinois 61401
    United States

    Active - Recruiting

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois 60134
    United States

    Active - Recruiting

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois 61443
    United States

    Active - Recruiting

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois 60045
    United States

    Active - Recruiting

  • Illinois CancerCare-Macomb

    Macomb, Illinois 61455
    United States

    Active - Recruiting

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois 61938
    United States

    Active - Recruiting

  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois 62864
    United States

    Active - Recruiting

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois 62269
    United States

    Active - Recruiting

  • Northwestern Medicine Orland Park

    Orland Park, Illinois 60462
    United States

    Active - Recruiting

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois 61350
    United States

    Active - Recruiting

  • Illinois CancerCare-Pekin

    Pekin, Illinois 61554
    United States

    Active - Recruiting

  • Illinois CancerCare-Peoria

    Peoria, Illinois 61615
    United States

    Active - Recruiting

  • Methodist Medical Center of Illinois

    Peoria, Illinois 61636
    United States

    Active - Recruiting

  • Illinois CancerCare-Peru

    Peru, Illinois 61354
    United States

    Active - Recruiting

  • Valley Radiation Oncology

    Peru, Illinois 61354
    United States

    Active - Recruiting

  • Illinois CancerCare-Princeton

    Princeton, Illinois 61356
    United States

    Active - Recruiting

  • SwedishAmerican Regional Cancer Center/ACT

    Rockford, Illinois 61114
    United States

    Active - Recruiting

  • Memorial Medical Center

    Springfield, Illinois 62781
    United States

    Active - Recruiting

  • Southern Illinois University School of Medicine

    Springfield, Illinois 62702
    United States

    Active - Recruiting

  • Springfield Clinic

    Springfield, Illinois 62702
    United States

    Active - Recruiting

  • Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Active - Recruiting

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois 60555
    United States

    Active - Recruiting

  • Illinois CancerCare - Washington

    Washington, Illinois 61571
    United States

    Active - Recruiting

  • Rush-Copley Healthcare Center

    Yorkville, Illinois 60560
    United States

    Active - Recruiting

  • Reid Health

    Richmond, Indiana 47374
    United States

    Active - Recruiting

  • Mercy Hospital

    Cedar Rapids, Iowa 52403
    United States

    Active - Recruiting

  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa 52403
    United States

    Active - Recruiting

  • Medical Oncology and Hematology Associates-West Des Moines

    Clive, Iowa 50325
    United States

    Active - Recruiting

  • Mercy Cancer Center-West Lakes

    Clive, Iowa 50325
    United States

    Active - Recruiting

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa 51503
    United States

    Active - Recruiting

  • Greater Regional Medical Center

    Creston, Iowa 50801
    United States

    Active - Recruiting

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314
    United States

    Active - Recruiting

  • Mission Cancer and Blood - Laurel

    Des Moines, Iowa 50314
    United States

    Active - Recruiting

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa 50266
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Chanute

    Chanute, Kansas 66720
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Dodge City

    Dodge City, Kansas 67801
    United States

    Active - Recruiting

  • Cancer Center of Kansas - El Dorado

    El Dorado, Kansas 67042
    United States

    Active - Recruiting

  • Central Care Cancer Center - Garden City

    Garden City, Kansas 67846
    United States

    Active - Recruiting

  • Central Care Cancer Center - Great Bend

    Great Bend, Kansas 67530
    United States

    Active - Recruiting

  • HaysMed University of Kansas Health System

    Hays, Kansas 67601
    United States

    Active - Recruiting

  • Cancer Center of Kansas-Independence

    Independence, Kansas 67301
    United States

    Active - Recruiting

  • University of Kansas Cancer Center

    Kansas City, Kansas 66160
    United States

    Active - Recruiting

  • Cancer Center of Kansas-Kingman

    Kingman, Kansas 67068
    United States

    Active - Recruiting

  • Lawrence Memorial Hospital

    Lawrence, Kansas 66044
    United States

    Active - Recruiting

  • Cancer Center of Kansas-Liberal

    Liberal, Kansas 67905
    United States

    Active - Recruiting

  • Cancer Center of Kansas-Manhattan

    Manhattan, Kansas 66502
    United States

    Active - Recruiting

  • Cancer Center of Kansas - McPherson

    McPherson, Kansas 67460
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Newton

    Newton, Kansas 67114
    United States

    Active - Recruiting

  • Olathe Health Cancer Center

    Olathe, Kansas 66061
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Parsons

    Parsons, Kansas 67357
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Pratt

    Pratt, Kansas 67124
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Salina

    Salina, Kansas 67401
    United States

    Active - Recruiting

  • Salina Regional Health Center

    Salina, Kansas 67401
    United States

    Active - Recruiting

  • University of Kansas Health System Saint Francis Campus

    Topeka, Kansas 66606
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Wellington

    Wellington, Kansas 67152
    United States

    Active - Recruiting

  • Ascension Via Christi Hospitals Wichita

    Wichita, Kansas 67214
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Wichita

    Wichita, Kansas 67214
    United States

    Active - Recruiting

  • Cancer Center of Kansas-Wichita Medical Arts Tower

    Wichita, Kansas 67208
    United States

    Active - Recruiting

  • Cancer Center of Kansas - Winfield

    Winfield, Kansas 67156
    United States

    Active - Recruiting

  • Flaget Memorial Hospital

    Bardstown, Kentucky 40004
    United States

    Active - Recruiting

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky 40701
    United States

    Active - Recruiting

  • Saint Joseph Hospital

    Lexington, Kentucky 40504
    United States

    Active - Recruiting

  • Saint Joseph Hospital East

    Lexington, Kentucky 40509
    United States

    Active - Recruiting

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky 40504
    United States

    Active - Recruiting

  • Saint Joseph London

    London, Kentucky 40741
    United States

    Active - Recruiting

  • Saint Joseph Mount Sterling

    Mount Sterling, Kentucky 40353
    United States

    Active - Recruiting

  • Louisiana State University Health Science Center

    New Orleans, Louisiana 70112
    United States

    Active - Recruiting

  • University Medical Center New Orleans

    New Orleans, Louisiana 70112
    United States

    Active - Recruiting

  • Christiana Care - Union Hospital

    Elkton, Maryland 21921
    United States

    Active - Recruiting

  • Beverly Hospital

    Beverly, Massachusetts 01915
    United States

    Active - Recruiting

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts 01805
    United States

    Active - Recruiting

  • Addison Gilbert Hospital

    Gloucester, Massachusetts 01930
    United States

    Active - Recruiting

  • Lahey Medical Center-Peabody

    Peabody, Massachusetts 01960
    United States

    Active - Recruiting

  • Winchester Hospital

    Winchester, Massachusetts 01890
    United States

    Active - Recruiting

  • Hickman Cancer Center

    Adrian, Michigan 49221
    United States

    Active - Recruiting

  • Saint Joseph Mercy Hospital

    Ann Arbor, Michigan 48106
    United States

    Active - Recruiting

  • Saint Joseph Mercy Brighton

    Brighton, Michigan 48114
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan 48114
    United States

    Active - Recruiting

  • Saint Joseph Mercy Canton

    Canton, Michigan 48188
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan 48188
    United States

    Active - Recruiting

  • Caro Cancer Center

    Caro, Michigan 48723
    United States

    Active - Recruiting

    See Also
    Intermountain Health hiring Sonographer in Thornton, Colorado, United States | LinkedIn

  • Saint Joseph Mercy Chelsea

    Chelsea, Michigan 48118
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan 48118
    United States

    Active - Recruiting

  • Hematology Oncology Consultants-Clarkston

    Clarkston, Michigan 48346
    United States

    Active - Recruiting

  • Newland Medical Associates-Clarkston

    Clarkston, Michigan 48346
    United States

    Active - Recruiting

  • Beaumont Hospital - Dearborn

    Dearborn, Michigan 48124
    United States

    Active - Recruiting

  • Ascension Saint John Hospital

    Detroit, Michigan 48236
    United States

    Active - Recruiting

  • Great Lakes Cancer Management Specialists-Doctors Park

    East China Township, Michigan 48054
    United States

    Active - Recruiting

  • Beaumont Hospital - Farmington Hills

    Farmington Hills, Michigan 48336
    United States

    Active - Recruiting

  • Genesee Cancer and Blood Disease Treatment Center

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Genesee Hematology Oncology PC

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Academic Hematology Oncology Specialists

    Grosse Pointe Woods, Michigan 48236
    United States

    Active - Recruiting

  • Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Active - Recruiting

  • Sparrow Hospital

    Lansing, Michigan 48912
    United States

    Active - Recruiting

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan 48154
    United States

    Active - Recruiting

  • Great Lakes Cancer Management Specialists-Macomb Medical Campus

    Macomb, Michigan 48044
    United States

    Active - Recruiting

  • Saint Mary's Oncology/Hematology Associates of Marlette

    Marlette, Michigan 48453
    United States

    Active - Recruiting

  • Toledo Clinic Cancer Centers-Monroe

    Monroe, Michigan 48162
    United States

    Active - Recruiting

  • 21st Century Oncology-Pontiac

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Hope Cancer Center

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Newland Medical Associates-Pontiac

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Saint Joseph Mercy Oakland

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Cancer Care Associates PC

    Royal Oak, Michigan 48073
    United States

    Active - Recruiting

  • Comprehensive Medical Center PLLC

    Royal Oak, Michigan 48073
    United States

    Active - Recruiting

  • Hematology Oncology Consultants PC

    Royal Oak, Michigan 48073
    United States

    Active - Recruiting

  • Oakland Colon Rectal Associates

    Royal Oak, Michigan 48067
    United States

    Active - Recruiting

  • Oakland Medical Group

    Royal Oak, Michigan 48073
    United States

    Active - Recruiting

  • William Beaumont Hospital-Royal Oak

    Royal Oak, Michigan 48073
    United States

    Active - Recruiting

  • Ascension Saint Mary's Hospital

    Saginaw, Michigan 48601
    United States

    Active - Recruiting

  • Oncology Hematology Associates of Saginaw Valley PC

    Saginaw, Michigan 48604
    United States

    Active - Recruiting

  • Bhadresh Nayak MD PC-Sterling Heights

    Sterling Heights, Michigan 48312
    United States

    Active - Recruiting

  • Premier Hematology Oncology Care

    Sterling Heights, Michigan 48312
    United States

    Active - Recruiting

  • Ascension Saint Joseph Hospital

    Tawas City, Michigan 48764
    United States

    Active - Recruiting

  • Hematology Oncology Consultants PC-Troy

    Troy, Michigan 48098
    United States

    Active - Recruiting

  • Michigan Institute of Urology-Town Center

    Troy, Michigan 48084
    United States

    Active - Recruiting

  • William Beaumont Hospital - Troy

    Troy, Michigan 48085
    United States

    Active - Recruiting

  • Advanced Breast Care Center PLLC

    Warren, Michigan 48088
    United States

    Active - Recruiting

  • Great Lakes Cancer Management Specialists-Macomb Professional Building

    Warren, Michigan 48093
    United States

    Active - Recruiting

  • Macomb Hematology Oncology PC

    Warren, Michigan 48093
    United States

    Active - Recruiting

  • Michigan Breast Specialists-Warren

    Warren, Michigan 48093
    United States

    Active - Recruiting

  • Saint John Macomb-Oakland Hospital

    Warren, Michigan 48093
    United States

    Active - Recruiting

  • Saint Mary's Oncology/Hematology Associates of West Branch

    West Branch, Michigan 48661
    United States

    Active - Recruiting

  • Huron Gastroenterology PC

    Ypsilanti, Michigan 48106
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan 48197
    United States

    Active - Recruiting

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota 56601
    United States

    Active - Recruiting

  • Minnesota Oncology - Burnsville

    Burnsville, Minnesota 55337
    United States

    Active - Recruiting

  • Cambridge Medical Center

    Cambridge, Minnesota 55008
    United States

    Active - Recruiting

  • Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Active - Recruiting

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Active - Recruiting

  • Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota 55369
    United States

    Active - Recruiting

  • Minnesota Oncology Hematology PA-Maplewood

    Maplewood, Minnesota 55109
    United States

    Active - Recruiting

  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota 55109
    United States

    Active - Recruiting

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Active - Recruiting

  • Health Partners Inc

    Minneapolis, Minnesota 55454
    United States

    Active - Recruiting

  • Hennepin County Medical Center

    Minneapolis, Minnesota 55415
    United States

    Active - Recruiting

  • Monticello Cancer Center

    Monticello, Minnesota 55362
    United States

    Active - Recruiting

  • New Ulm Medical Center

    New Ulm, Minnesota 56073
    United States

    Active - Recruiting

  • Fairview Northland Medical Center

    Princeton, Minnesota 55371
    United States

    Active - Recruiting

  • North Memorial Medical Health Center

    Robbinsdale, Minnesota 55422
    United States

    Active - Recruiting

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota 55416
    United States

    Active - Recruiting

  • Regions Hospital

    Saint Paul, Minnesota 55101
    United States

    Active - Recruiting

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Active - Recruiting

  • Saint Francis Regional Medical Center

    Shakopee, Minnesota 55379
    United States

    Active - Recruiting

  • Lakeview Hospital

    Stillwater, Minnesota 55082
    United States

    Active - Recruiting

  • Sanford Thief River Falls Medical Center

    Thief River Falls, Minnesota 56701
    United States

    Active - Recruiting

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Active - Recruiting

  • Rice Memorial Hospital

    Willmar, Minnesota 56201
    United States

    Active - Recruiting

  • Minnesota Oncology Hematology PA-Woodbury

    Woodbury, Minnesota 55125
    United States

    Active - Recruiting

  • Sanford Cancer Center Worthington

    Worthington, Minnesota 56187
    United States

    Active - Recruiting

  • Fairview Lakes Medical Center

    Wyoming, Minnesota 55092
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi 39705
    United States

    Active - Recruiting

  • Baptist Cancer Center-Grenada

    Grenada, Mississippi 38901
    United States

    Active - Recruiting

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Union County

    New Albany, Mississippi 38652
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Oxford

    Oxford, Mississippi 38655
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Desoto

    Southhaven, Mississippi 38671
    United States

    Active - Recruiting

  • Saint Louis Cancer and Breast Institute-Ballwin

    Ballwin, Missouri 63011
    United States

    Active - Recruiting

  • Central Care Cancer Center - Bolivar

    Bolivar, Missouri 65613
    United States

    Active - Recruiting

  • Cox Cancer Center Branson

    Branson, Missouri 65616
    United States

    Active - Recruiting

  • Saint Francis Medical Center

    Cape Girardeau, Missouri 63703
    United States

    Active - Recruiting

  • Southeast Cancer Center

    Cape Girardeau, Missouri 63703
    United States

    Active - Recruiting

  • Parkland Health Center - Farmington

    Farmington, Missouri 63640
    United States

    Active - Recruiting

  • Capital Region Southwest Campus

    Jefferson City, Missouri 65109
    United States

    Active - Recruiting

  • Freeman Health System

    Joplin, Missouri 64804
    United States

    Active - Recruiting

  • Mercy Hospital Joplin

    Joplin, Missouri 64804
    United States

    Active - Recruiting

  • Truman Medical Centers

    Kansas City, Missouri 64108
    United States

    Active - Recruiting

  • Lake Regional Hospital

    Osage Beach, Missouri 65065
    United States

    Active - Recruiting

  • Delbert Day Cancer Institute at PCRMC

    Rolla, Missouri 65401
    United States

    Active - Recruiting

  • Mercy Clinic-Rolla-Cancer and Hematology

    Rolla, Missouri 65401
    United States

    Active - Recruiting

  • Heartland Regional Medical Center

    Saint Joseph, Missouri 64506
    United States

    Active - Recruiting

  • Mercy Hospital Saint Louis

    Saint Louis, Missouri 63141
    United States

    Active - Recruiting

  • Mercy Hospital South

    Saint Louis, Missouri 63128
    United States

    Active - Recruiting

  • Missouri Baptist Medical Center

    Saint Louis, Missouri 63131
    United States

    Active - Recruiting

  • Saint Louis Cancer and Breast Institute-South City

    Saint Louis, Missouri 63109
    United States

    Active - Recruiting

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri 63670
    United States

    Active - Recruiting

  • CoxHealth South Hospital

    Springfield, Missouri 65807
    United States

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    Springfield, Missouri 65804
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    Sullivan, Missouri 63080
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    Sunset Hills, Missouri 63127
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    Washington, Missouri 63090
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    Anaconda, Montana 59711
    United States

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    Billings, Montana 59101
    United States

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    Bozeman, Montana 59715
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    Great Falls, Montana 59405
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    Great Falls, Montana 59405
    United States

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    Kalispell, Montana 59901
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  • Community Medical Hospital

    Missoula, Montana 59804
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  • Saint Patrick Hospital - Community Hospital

    Missoula, Montana 59802
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  • CHI Health Good Samaritan

    Kearney, Nebraska 68847
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  • Saint Elizabeth Regional Medical Center

    Lincoln, Nebraska 68510
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    Omaha, Nebraska 68124
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    Omaha, Nebraska 68122
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    Omaha, Nebraska 68130
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  • Creighton University Medical Center

    Omaha, Nebraska 68131
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  • Midlands Community Hospital

    Papillion, Nebraska 68046
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  • Glens Falls Hospital

    Glens Falls, New York 12801
    United States

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  • Stony Brook University Medical Center

    Stony Brook, New York 11794
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  • South Nassau Cancer Center

    Valley Stream, New York 11580
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    Asheville, North Carolina 28803
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    Clyde, North Carolina 28721
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    Hendersonville, North Carolina 28792
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  • Margaret R Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
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    Pinehurst, North Carolina 28374
    United States

    Active - Recruiting

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    Weaverville, North Carolina 28787
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  • Sanford Bismarck Medical Center

    Bismarck, North Dakota 58501
    United States

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    Fargo, North Dakota 58122
    United States

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    Fargo, North Dakota 58104
    United States

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    Fargo, North Dakota 58122
    United States

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  • Sanford South University Medical Center

    Fargo, North Dakota 58103
    United States

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  • Southpointe-Sanford Medical Center Fargo

    Fargo, North Dakota 58103
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  • Indu and Raj Soin Medical Center

    Beavercreek, Ohio 45431
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  • Saint Elizabeth Boardman Hospital

    Boardman, Ohio 44512
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  • Dayton Physicians LLC-Miami Valley South

    Centerville, Ohio 45459
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    Centerville, Ohio 45459
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    Cincinnati, Ohio 45242
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    Cincinnati, Ohio 45236
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    Cincinnati, Ohio 45255
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    Cincinnati, Ohio 45247
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    Dayton, Ohio 45409
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    Dayton, Ohio 45415
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    Dayton, Ohio 45409
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    Dayton, Ohio 45415
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    Findlay, Ohio 45840
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    Findlay, Ohio 45840
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    Findlay, Ohio 45840
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    Franklin, Ohio 45005-1066
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    Franklin, Ohio 45005
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    Greenville, Ohio 45331
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    Greenville, Ohio 45331
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    Kettering, Ohio 45409
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    Kettering, Ohio 45429
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    Maumee, Ohio 43537
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    Toledo, Ohio 43623
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  • Dayton Physicians LLC - Troy

    Troy, Ohio 45373
    United States

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  • Upper Valley Medical Center

    Troy, Ohio 45373
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  • Saint Joseph Warren Hospital

    Warren, Ohio 44484
    United States

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  • Saint Elizabeth Youngstown Hospital

    Youngstown, Ohio 44501
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    Oklahoma City, Oklahoma 73120
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  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104
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    Baker City, Oregon 97814
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    Bend, Oregon 97701
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    Clackamas, Oregon 97015
    United States

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    Clackamas, Oregon 97015
    United States

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  • Bay Area Hospital

    Coos Bay, Oregon 97420
    United States

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    Gresham, Oregon 97030
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    Newberg, Oregon 97132
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    Ontario, Oregon 97914
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    Oregon City, Oregon 97045
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    Portland, Oregon 97210
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    Portland, Oregon 97213
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    Portland, Oregon 97225
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    Redmond, Oregon 97756
    United States

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    Tualatin, Oregon 97062
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    Allentown, Pennsylvania 18103
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    Bethlehem, Pennsylvania 18017
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    Bryn Mawr, Pennsylvania 19010
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    Chadds Ford, Pennsylvania 19317
    United States

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    Collegeville, Pennsylvania 19426
    United States

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    East Stroudsburg, Pennsylvania 18301
    United States

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    Exton, Pennsylvania 19341
    United States

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    Hazleton, Pennsylvania 18201
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    Media, Pennsylvania 19063
    United States

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    Newtown Square, Pennsylvania 19073
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    Paoli, Pennsylvania 19301
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  • Lankenau Medical Center

    Wynnewood, Pennsylvania 19096
    United States

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  • Women and Infants Hospital

    Providence, Rhode Island 02905
    United States

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  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina 29316
    United States

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    Easley, South Carolina 29640
    United States

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    Greenville, South Carolina 29605
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    Greenville, South Carolina 29615
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    Greenville, South Carolina 29605
    United States

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    Greer, South Carolina 29650
    United States

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  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina 29672
    United States

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  • Lexington Medical Center

    West Columbia, South Carolina 29169
    United States

    Active - Recruiting

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota 57104
    United States

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    Sioux Falls, South Dakota 57117-5134
    United States

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    Collierville, Tennessee 38017
    United States

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    Memphis, Tennessee 38120
    United States

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  • Bon Secours Memorial Regional Medical Center

    Mechanicsville, Virginia 23116
    United States

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  • Bon Secours Saint Francis Medical Center

    Midlothian, Virginia 23114
    United States

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  • Bon Secours Westchester Emergency Center

    Midlothian, Virginia 23113
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  • Bon Secours Cancer Institute at Reynolds Crossing

    Richmond, Virginia 23230
    United States

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  • Bon Secours Richmond Community Hospital

    Richmond, Virginia 23223
    United States

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  • Bon Secours Saint Mary's Hospital

    Richmond, Virginia 23226
    United States

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    Aberdeen, Washington 98520
    United States

    Active - Recruiting

  • PeaceHealth Saint Joseph Medical Center

    Bellingham, Washington 98225
    United States

    Active - Recruiting

  • Harrison Medical Center

    Bremerton, Washington 98310
    United States

    Active - Recruiting

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    Centralia, Washington 98531
    United States

    Active - Recruiting

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    Edmonds, Washington 98026
    United States

    Active - Recruiting

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    Everett, Washington 98201
    United States

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    Issaquah, Washington 98029
    United States

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    Kennewick, Washington 99336
    United States

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    Lacey, Washington 98503
    United States

    Active - Recruiting

  • PeaceHealth Saint John Medical Center

    Longview, Washington 98632
    United States

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  • Swedish Medical Center-Ballard Campus

    Seattle, Washington 98107
    United States

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    Seattle, Washington 98122-5711
    United States

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    Seattle, Washington 98122
    United States

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    Sedro-Woolley, Washington 98284
    United States

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    Shelton, Washington 98584
    United States

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    Vancouver, Washington 98684
    United States

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    Vancouver, Washington 98686
    United States

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    Vancouver, Washington 98664
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    Walla Walla, Washington 99362
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    Yelm, Washington 98597
    United States

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    Eau Claire, Wisconsin 54701
    United States

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    Marshfield, Wisconsin 54449
    United States

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    Minocqua, Wisconsin 54548
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    New Richmond, Wisconsin 54017
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    Rice Lake, Wisconsin 54868
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    Stevens Point, Wisconsin 54482
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    Weston, Wisconsin 54476
    United States

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    Cody, Wyoming 82414
    United States

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    Sheridan, Wyoming 82801
    United States

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer | Clinical Research Trial Listing (2025)

FAQs

What shorter chemo immunotherapy without anthracycline drugs for early stage triple-negative breast cancer? ›

Pembrolizumab may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Shorter treatment without anthracycline chemotherapy may work the same as the usual anthracycline chemotherapy treatment for early-stage triple negative breast cancer.

Get More Info ›
What is the new immunotherapy drug for triple-negative breast cancer? ›

Pembrolizumab Improves Survival in Advanced Triple-Negative Breast Cancer. Adding the immunotherapy drug pembrolizumab (Keytruda) to chemotherapy can help some patients with advanced triple-negative breast cancer live longer than if they received chemotherapy alone, new results from a clinical trial show.

View Details ›
What is the success rate of immunotherapy for triple-negative breast cancer? ›

“Triple-negative breast cancer is the only type of breast cancer we treat with immunotherapy,” said Stephen Shiao, MD, PhD, co-director of the Cancer Therapeutics Program at Cedars-Sinai Cancer and first author of the study. “Unfortunately, only 20% to 30% of patients respond to immunotherapy on its own.

Read More ›
What is the best chemo for triple-negative breast cancer? ›

Stage IV triple-negative breast cancer

Chemo is often used first when the cancer has spread to other parts of the body (stage IV). Common chemo drugs used include anthracyclines, taxanes, capecitabine, gemcitabine, eribulin, and others.

Tell Me More ›
How well does triple-negative breast cancer respond to chemo? ›

Around 40–50% of all triple-negative breast cancer (TNBC) patients achieve a pathological complete response (pCR) after treatment with neoadjuvant chemotherapy (NAC). The identification of biomarkers predicting the response to NAC could be helpful for personalized treatment.

Read The Full Story ›
Can you skip chemo with triple-negative breast cancer? ›

What types of breast cancer should be treated with chemotherapy? Almost all women with HER2-positive cancers still need some amount of chemotherapy. And women with triple-negative tumors still need a relatively intensive course of chemotherapy, Dr. Lustberg says.

Explore More ›
What not to eat with triple-negative breast cancer? ›

The ACS advises people to limit or avoid the following foods and beverages: red and processed meats. sugar-sweetened drinks. highly processed foods.

Read More ›
What is the life expectancy for triple-negative breast cancer? ›

5-year relative survival rates for triple-negative breast cancer
SEER Stage5-year Relative Survival Rate
Localized91%
Regional66%
Distant12%
All stages combined77%

Show Me More ›
What is the new cancer breakthrough in 2024? ›

On April 7, 2024, sunvozertinib (DZD9008) was granted a breakthrough therapy designation from the FDA as a first-line treatment for a specific type of lung cancer. The FDA accepted the new drug application of SH-201 for review as a potential treatment for certain forms of leukemia and other cancers on April 8, 2024.

See Details ›
What is the latest treatment for triple-negative breast cancer? ›

The immunotherapy approved for the treatment of triple-negative breast cancer is called pembrolizumab. It can be used with chemotherapy or other medicines before surgery and then continued alone after surgery to treat early stage, triple-negative breast cancer at high risk of recurrence.

Discover More ›

What are the side effects of immunotherapy for triple-negative breast cancer? ›

Side effects of these drugs can include fatigue, cough, nausea, skin rash, poor appetite, constipation, and diarrhea. Other, more serious side effects occur less often. Infusion reactions: Some people might have an infusion reaction while getting these drugs.

Read The Full Story ›
What is considered early stage TNBC? ›

At stage 1, triple-negative breast cancer is characterized by a relatively small tumor, usually less than 2 centimeters in diameter. Although cancer cells may have infiltrated nearby breast tissues, they have not spread to surrounding lymph nodes or metastasized to distant organs.

Continue Reading ›
What is the new treatment for breast cancer in 2024? ›

From 1 May 2024, Verzenio will be expanded on the PBS to treat patients with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), lymph node positive, invasive, resected early breast cancer at high risk of disease recurrence.

Continue Reading ›
What is the gold standard treatment for triple-negative breast cancer? ›

Chemotherapy is the most common of these options. TNBC is generally treated with systemic chemotherapy using drugs such as anthracyclines and taxanes in neoadjuvant or adjuvant settings.

Explore More ›
How do you beat triple-negative breast cancer? ›

Newer medicines called poly (ADP-ribose) polymerase inhibitors or PARP inhibitors can destroy cancer cells, and are now FDA-approved to treat triple-negative breast cancer. Immunotherapy helps your body see the malignant cells as harmful invaders so your immune system can fight the cancer.

Continue Reading ›
What immunotherapy is used for TNBC? ›

Pembrolizumab (Keytruda) is used: in combination with chemotherapy before surgery (called neoadjuvant therapy) for high-risk early-stage TNBC. after surgery for TNBC by itself, and continued until the cancer stops responding.

See More ›
What is the first line of chemotherapy for triple-negative breast cancer? ›

Cisplatin combined with nab-paclitaxel or paclitaxel is the preferred first-line treatment for mTNBC. For PD-L1 and BRCA mutation-positive tumors, atezolizumab/pembrolizumab combined with nab-paclitaxel and talazoparib is an effective treatment option.

Continue Reading ›
How is early stage triple-negative breast cancer treated? ›

Stages 1-3 triple-negative breast cancer: If the tumor is small, breast-conserving surgery (lumpectomy) may be recommended. If there is lymph node involvement, a mastectomy and lymph node removal may be performed. If the tumor is large or if the cancer has spread to the lymph nodes, radiation may follow surgery.

Learn More ›
What is the second line treatment for triple-negative breast cancer? ›

Against all the chemotherapy agents, sacituzumab did better, so essentially that's why it's used currently in the secondline metastatic TNBC setting. The responses based on BRCA in patients who had germline BRCA mutation vs wild type had similar improvements in PFS and OS.

Continue Reading ›

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